More than 6.5 million Floridians voted to approve an amendment to the state’s Constitution that allows the right for people with one or more approved Debilitating Medical Conditions to use physician-approved marijuana. Amendment 2, however, does not require any accommodation for the on-site medical use of marijuana in any place of employment, nor does it require health insurance providers to reimburse expenses related to its medical use. Of importance is that marijuana is an illegal drug under federal law. Furthermore, the Americans with Disabilities Act does not cover individuals who are currently using drugs that are illegal under federal law. Employers should begin to adapt to Amendment 2 by updating handbooks and policies to clarify use of the substance.