According to a study by Johns Hopkins University, the third leading cause of death in the United States is medical malpractice. In response, the Department of Health and Human Services’ (HHS) guide has identified four key areas healthcare organizations should examine to prevent medical errors, including breakdowns in communication, medication-related errors, factors influencing incorrect or incomplete diagnosis, and factors related to fragmentation of the healthcare system. A systems-based approach can be helpful during times of crisis and allows organizations to work under consistent objectives, strategies, and tactics, ultimately mitigating risk. The HHS Office of the Assistant Secretary for Preparedness and Response recommends applying management methodology to the initial development of an Emergency Operations Plan (EOP). Other options to help mitigate risk include no-blame models and accountability-based systems.