The Office of Inspector General (OIG) exclusion list is one way healthcare facilities can meet legal, ethical, and professional standards while ensuring compliance, program integrity, and patient safety. Failing to comply could lead to fines, loss of federal program reimbursement and eligibility, and even litigation. Practitioners, employees, contractors, and subcontractors should be screened against the List of Excluded Individuals and Entities (LEIE) and monitored monthly for exclusion. Employees also should be cross-checked against the General Services Administration’s (GSA) System for Award Management (SAM) and state exclusion lists. Though daunting, building an effective exclusion monitoring program includes using the right automation, tools and having the most up-to-day provider data.