Urine is the preferred testing matrix for routine random drug testing in safety-sensitive industries due to its non-invasive collection, cost-effectiveness, and ability to detect a wide range of substances. This method provides a reliable indicator of recent drug use, ensuring workplace safety and compliance with regulatory standards. There are several advantages of urine testing, most importantly in maintaining a drug-free environment in industries where safety is paramount. Urine is effective, reliable and practical as a testing matrix for maintaining safety and productivity in the workplace.